Genotype-dependent modification of Sarcoma 37 growth in castrated mice.

Sarcoma 37 cells grew more rapidly in castrated male mice than in controls of the same genotype; however, this effect of castration was dependent on the host genotype. Among inbred YS/Wf mice, tumor weight was increased only in castrated yellow Ay/a males and not in the comparable black a/a males. In contrast, mean tumor weight was increased in both yellow Avy/a and black a/a castrated males of the inbred VY/Wf